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Network Biology, 2012, 2(2): 45-56
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Article

Identifying the common interaction networks of amoeboid motility and cancer cell metastasis

Ahmed H. Zeitoun, Shady S. Ibrahim, Christoph P. Bagowski
1German University Cairo, Faculty of Pharmacy and Biotechnology, New Cairo City, Egypt
2ETH Zurich, Institute of Biochemistry, SchafmattstraBe 18, 8093 Zurich, Switzerland
3Ernst-Moritz Arndt University Greifswald, Friedrich Loffler StraBe 23a, 17475 Greifswald, Germany

Received 6 February 2012;Accepted 10 March 2012;Published online 1 June 2012
IAEES

Abstract
The recently analyzed genome of Naegleria gruberi, a free-living amoeboflagellate of the Heterolobosea clade, revealed a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal-, motility- and signaling-genes. This protist, which diverged from other eukaryotic lineages over a billion years ago, possesses the ability for both amoeboid and flagellar motility. In a phylogenomic comparison of two free living eukaryotes with large proteomic datasets of three metastatic tumour entities (malignant melanoma, breast- and prostate-carcinoma), we find common proteins with potential importance for cell motility and cancer cell metastasis. To identify the underlying signaling modules, we constructed for each tumour type a protein-protein interaction network including these common proteins. The connectivity within this interactome revealed specific interactions and pathways which constitute prospective points of intervention for novel anti-metastatic tumour therapies.

Keywords movement; invasion; protein interaction network; PDZ domain; Proteome; cancer; tumour;interactome; prostate; breast carcinoma; metastatic behaviour.



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