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Network Biology, 2012, 2(3): 95-109
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Article

Analysis on degree distribution of tumor signaling networks

JingQiu Huang, WenJun Zhang
1School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
2International Academy of Ecology and Environmental Sciences, Hong Kong

Received 7 June 2012;Accepted 20 July 2012;Published online 1 September 2012
IAEES

Abstract
Tumorigenesis is a multi-factorial and multi-step process, among which the changes in cell signaling pathways play a key role. Up till now there are fewer studies on network structure of tumor signaling pathways. In present study the degree distribution was analyzed based on thirty kinds of tumor signaling networks, including VEGF-pathway, JNK-pathway, p53-signaling, etc. The results showed that almost all of them were scale-free complex networks. Key metabolites in some tumor networks were also described.

Keywords tumor;cancer;signaling pathway;network;degree distribution.


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