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Network Biology, 2013, 3(3): 87-96
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Article

Functional interactome of Aquaporin 1 sub-family reveals new physiological functions in Arabidopsis Thaliana

Mohamed Ragab Abdel Gawwad1, Jasmin Sutkovic1, Lavinija Matakovic2, Mohamed Musrati1, Lizhi Zhang3
1Genetics and Bioengineering department, International University of Sarajevo, Ilidza, 71220 Bosnia and Herzegovina
2University of Josip Jurja Strossmayer, Biology Department, Croatia
3Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA

Received 12 July 2013;Accepted 25 July 2013;Published online 1 September 2013
IAEES

Abstract
Aquaporins are channel proteins found in plasma membranes and intercellular membranes of different cellular compartments, facilitate the water flux, solutes and gases across the cellular plasma membranes. The present study highlights the sub-family plasma membrane intrinsic protein (PIP) predicting the 3-D structure and analyzing the functional interactome of it homologs. PIP1 homologs integrate with many proteins with different plant physiological roles in Arabidopsis thaliana including; PIP1A and PIP1B: facilitate the transport of water, diffusion of amino acids and/or peptides from the vacuolar compartment to the cytoplasm, play a role in the control of cell turgor and cell expansion and involved in root water uptake respectively. In addition we found that PIP1B plays a defensive role against Pseudomonas syringae infection through the interaction with the plasma membrane Rps2 protein. Another substantial function of PIP1C via the interaction with PIP2E is the response to nematode infection. Generally, PIP1 sub-family interactome controlling many physiological processes in plant cell like; osmoregulation in plants under high osmotic stress such as under a high salt, response to nematode, facilitate the transport of water across cell membrane and regulation of floral initiation in Arabidopsis thaliana.

Keywords Aquaporins;Arabidopsis thaliana;interactome;3-D structure.


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