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Network Biology, 2015, 5(3): 82-94
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Article

Protein and mRNA levels support the notion that a genetic regulatory circuit controls growth phases in E. coli populations

Agustino Martinez-Antonio
Departamento de Ingenieria Genetica. Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional. Unidad Irapuato. Km. 9.6 Libramiento Norte Carretera Irapuato-Leon. CP 36821. Irapuato, Guanajuato. Mexico

Received 1 April 2015;Accepted 8 May 2015;Published online 1 September 2015
IAEES

Abstract
Bacterial populations transition between growing and non-growing phases, based on nutrient availability and stresses conditions. The hallmark of a growing state is anabolism, including DNA replication and cell division. In contrast, bacteria in a growth-arrested state acquire a resistant physiology and diminished metabolism. However, there is little knowledge on how this transition occurs at the molecular level. Here, we provide new evidence that a multi-element genetic regulatory circuit might work to maintain genetic control among growth-phase transitions in Escherichia coli. This work contributes to the discovering of design principles behind the performance of biological functions, which could be of relevance on the new disciplines of biological engineering and synthetic biology.

Keywords growth phase;regulatory circuit;proteome;mRNA;bacteria.



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