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Network Biology, 2017, 7(2): 41-56
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Article

Drug design and analysis for bipolar disorder and associated diseases: A bioinformatics approach

Nahida Habib1, Kawsar Ahmed2,3, Iffat Jabin1, Mohammad Motiur Rahman1
1Department of Computer Science and Engineering (CSE), Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail-1902, Bangladesh
2Department of Information and Communication Technology (ICT), Mawlana Bhashani Science and Technology University (MBSTU), Santosh, Tangail-1902, Bangladesh
3Group of Bio-photomatix, Santosh, Tangail-1902, Bangladesh

Received 27 April 2017;Accepted 19 May 2017;Published 1 June 2017
IAEES

Abstract
Bioinformatics deals with biological data and analyzes or processes the data using computer science techniques. With the appearance of modern bioinformatics tools, it is now possible to design a drug using these high technologies and open a new area of drug design and development. This research predicts to design a common drug for four associated mental disorders that include bipolar disorder, schizophrenia, coronary heart diseases and stroke. The key to drug design is a biomolecule or protein. To show the protein interactions and evolutions, a protein-protein interaction network is created among the common genes of the four diseases. The genes corresponding to each disease are collected from NCBI gene database. These genes are preprocessed, mined and verified to find the common genes among the diseases. After getting common genes (7 genes), PPI network is created with them. Then a common drug is designed that will work on four investigated diseases. This structure based drug design research will open a new era to discover and develop new drug compounds using different bioinformatics tools.

Keywords bioinformatics;mental disorders;bipolar disorder;schizophrenia;coronary heart diseases;stroke;PPI Network;drug design.


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