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Network Biology, 2018, 8(2): 90-97
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Article

A mathematical framework for understanding how lymph node architecture scales with host body size to produce an efficient immune response

S Banerjee
University of Oxford Mathematical Institute, Oxford, OX2 6GG, United Kingdom

Received 1 October 2017;Accepted 10 November 2017;Published 1 June 2018
IAEES

Abstract
The immune system can detect and respond against pathogens in time that does not vary with the size of the host animal. We suggest that this is due to the architecture of lymph nodes. Lymph nodes are anatomical structures that facilitate the otherwise serendipitous encounter of immune system cells with pathogens. We develop two complementary mathematical approaches to derive the optimal distribution of lymph nodes that enable a rapid immune response. Our work gives insights into the optimal design and architecture of the immune system and provides valuable inspiration for designing efficient computing systems.

Keywords immuno-computing;scale-invariant search and response;scaling in the immune system;lymph node scaling.

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