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Network Biology, 2019, 9(2): 28-41
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Article

Design of a common pathway drug for all types of cardiovascular diseases: A network biology approach

Al-Mustanjid Arif1, Chandan Mandal1, Md. Habibur Rahman1,2
1Department of Software Engineering, Daffodil International University (DIU), 102/1, Sukrabad, Dhanmondi, Dhaka-1207, Bangladesh
2Department of Information and Communication Technology, Mawlana Bhasani Science and Technology University (MBSTU), Santosh, Tangail-1902, Bangladesh

Received 26 March 2019;Accepted 10 April 2019;Published 1 June 2019
IAEES

Abstract
More than an era among all non-communicable diseases, cardiovascular diseases have become a major concern worldwide. Cardiovascular diseases have occurred around the world because of some common risk factors. Diseases have a genetic association indirectly or directly resulting from similar risk factors. A disease is caused when a gene misses out its normal activity and affects the body negatively. Several research works have revealed the ways of how a structure-based drug from key biomolecule or protein can be designed for diseases using modern bioinformatics techniques and tools in network biology. This study evaluates protein-protein interaction network and designs a common pathway drug for all types of cardiovascular diseases. The data mining application called knowledge discovery in database (KDD) has been applied and genes are filtered, pre-processed, transformed and mined to identify common cardiovascular disease genes. Cardiovascular disease genes are collected using R from the National Center for Biotechnology Information gene database. Unihi is used as a tool for achieving the goal.

Keywords cardiovascular disease;data mining;R;protein-protein interaction network;drug design.


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