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Network Biology, 2021, 11(3): 207-221
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Article

The potential role of non-coding RNAs RP11-573G6.6 and HCG11 in the regulation of mitochondrial gene expression in glioblastoma: A bioinformatics-based study

Mahya Payazdan1, Mohammad Shafiei1, Seyedeh Sahar Mortazavi Farsani2
1Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2Department of Genetics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran

Received 7 April 2021;Accepted 15 May 2021;Published 1 September 2021
IAEES

Abstract
Long non-coding RNAs (lncRNAs) have attracted lots of attention worldwide. With the rapid advances in bioinformatics, several lncRNAs have been identified in the last decade. Ample evidence has shown that lncRNAs are involved in different mechanisms and play chief roles in many biological processes. Therefore, dysregulations of lncRNAs are associated with human complex diseases including glioblastoma (GBM). In this study, we have used lncRNA high throughput data analysis and some databases about their expression level, function, etc. Currently, a limited number of GBM-related lncRNAs have been reported experimentally. Therefore, analyzing lncRNA-GBM associations and predicting potential lncRNAs would benefit mechanism understanding, diagnosis, treatment, and prevention of this tumor. Therefore, we applied in silico analysis to find GBM-related lncRNAs and select the most promising lncRNAs for experimental validation. According to the results RP11-573G6.6 and HCG11, lncRNAs play critical role in GBM pathogenesis and could be promising targets in novel therapeutic approaches.

Keywords Glioblastoma;in silico;lncRNAs;mitochondrial gene expression;RNA sequencing.


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