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Network Biology, 2021, 11(4): 274-276
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Article

Open questions: Reflections on intrinsically disordered proteins

Mouna Choura1, Ahmed Rebai2
1Biotechnology and Plant Improvement Laboratory, Center of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour Km 6, P.O.Box 1177, 3018 Sfax, Tunisia
2Laboratory of Molecular and Cellular Screening Processes, Center of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour Km 6, P.O.Box 1177, 3018 Sfax, Tunisia

Received 15 June 2021;Accepted 20 July 2021;Published 1 December 2021
IAEES

Abstract
Intrinsically Disordered Proteins or Regions (IDPs) are proteins that lack a predetermined 3D structure playing key cellular functions including regulation, signaling, and protein-protein/DNA interaction. IDPs are often involved in diseases such as cancer, cardiovascular and neurodegenerative diseases, and diabetes. IDPs have been shown to be attractive therapeutic targets and drug development. Intrigued by these controversial observations, some questions are raised: how IDPs are so common even under the scenario that they are unstable and linked to misfolding and diseases? Does the cellular regulation depend on disorder?

Keywords disorder;diseases;protein;regulation.


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