Home

Network Biology, 2023, 13(4): 155-185
[XML] [EndNote] [RefManager] [BibTex] [ Full PDF (973K)][Supplementary Material (1000K)] [Comment/Review Article]

Article

Construction and analysis of the protein-protein interaction network of visual system in Drosophila

JiaNing Sun, WenJun Zhang
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

Received 31 May 2023;Accepted 3 June 2023;Published online 3 June 2023;Published 1 December 2023
IAEES

Abstract
Insects are one of the most widely distributed animals on earth, and their visual systems have strong adaptability, deeply affecting their survival, reproduction, diet, and environmental adaptation. With the sequencing of the entire genome of Drosophila and the development of modern biotechnology, research on visual proteins has made significant progress. Currently, a large amount of visual protein data has been obtained through conventional experimental methods and high-throughput analysis technology, but the functions of most visual proteins are still unannotated. In addition, the current research focus mostly on individual proteins or single interactions, and there has been no comprehensive analysis of visual proteins as a whole. Therefore, in this article we used network biology methods to construct the protein-protein interaction network of visual system in Drosophila and further determine the crucial proteins in the network. We have mainly obtained seed proteins by searching a large number of literature related to visual proteins in Drosophila, and used the STRING database to obtain information on protein-protein interactions to construct the protein-protein interaction network of visual system. The clusterProfiler software package was used for functional enrichment analysis. The protein-protein interaction network constructed using Cytoscape software included 248 proteins and 2948 interactions, and the crucial proteins in the network are Akt1, arm, Src42A, Pten, Rho1, norpA, and Egfr, etc. They are crucial visual proteins in Drosophila. These proteins play an important role in the network structure.The results showed that visual proteins play an important role in biological rhythms, morphogenesis, and basic metabolism of the insect.

Keywords Drosophila;visual system;protein-protein interaction network;network construction;network analysis;crucial proteins.


International Academy of Ecology and Environmental Sciences. E-mail: office@iaees.org
Copyright © 2009-2024 International Academy of Ecology and Environmental Sciences. All rights reserved.
Web administrator: office@iaees.org, website@iaees.org; Last modified: 2024/5/2


Translate page to: