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Network Biology, 2026, 16(2): 49-81
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Article

TraitGenePathAna: The AI-Powered biological trait analysis platform

WenJun Zhang
School of Life Sciences, Sun Yat-sen University, Guangzhou, China

Received 6 December 2025;Accepted 18 December 2025;Published online 25 December2025;Published 1 June 2026
IAEES

Abstract
The AI-Powered biological trait analysis platform, TraitGenePathAna, is a single-page web application that helps a user explore the biology behind a trait (e.g., longevity, disease resistance) for a chosen species (e.g., Homo sapiens, Drosophila melanogaster). It does this by sending a structured prompt to an LLM provider (DeepSeek or Google Gemini, etc.) and then presenting the model's response in a multi-tab results UI: (1) Overview: summary, significance, broad context; (2) Genetics: key genes, loci, heritability and gene-level discussion; (3) Pathways: molecular mechanisms, signaling cascades, network view; (4) Interventions: potential strategies and caveats (research, ethics, feasibility). In addition, the platform can conduct inferences on hidden rules, patterns, and relationships.

Keywords Artificial Intelligence (AI);biological trait;genes, pathways;web-based tool.


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