eng International Academy of Ecology and Environmental Sciences Network Pharmacology 2415-1084 2018-6-1 3 1-2 1 9 1 article WenJun Zhang 1 2 School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; International Academy of Ecology and Environmental Sciences, Hong Kong In present study, data of standardised death rates of malignant neoplasms per 100000 inhabitants in 31 European countries during 1994-2013 were used to analyze the profile and trend of cancer-induced deaths. The results showed that malignant neoplasm of trachea, bronchus and lung (about 25%) is the No. 1 cancer in 31 European countries, second by malignant neoplasm of prostate (men) (22%), third by malignant neoplasms of breast (women) (16%) and colon, rectosigmoid junction, rectum, anus and anal canal (16%). Finland, Bulgaria, Switherland, and Portugal, etc., are the countries with the least death rate of total cancers. Hungary has the highest death rate of total cancers in 31 European countries, followed by Croatia, etc. Portugal, Sweden and Finland, etc., have the least death rate, and Hungary, Denmark, Netherlands, and Poland have the highest in the death rate of malignant neoplasm of prostate (men). Romania, Malta, and Italy, etc., have the lowest rate, and Norway has one of the highest death rate in malignant neoplasm of prostate (men). Spain shows the lowest death rate, and Denmark and Malta have the highest death rate in malignant neoplasm of breast (women). Greece, Finland and Switzerland are the three countries with the least death rate and Hungary has the highest in death rate in malignant neoplasm of colon, rectosigmoid junction, rectum, anus and anal canal. In average, the standardized death rates of all types of cancers in recorded European countries declined significantly during the recorded period 1994-2013. Death rate of all childhood cancers in Bulgaria and Estonia declines mostly in 31 countries, followed by Romania and Czech. Czech, Poland, and Netherlands decline mostly in death rate of malignant neoplasm of trachea, bronchus and lung. Conversely, the death rate of Macedonia and Romania increases most significantly; Germany and Sweden increase in death rate also. Belgium declines mostly in death rate of malignant neoplasm of prostate (men), followed by France, Austria, etc. And Latvia and Estonia increase most quickly. Malta has the greatest decline in death rate of malignant neoplasm of breast (women), followed by Netherlands, Denmark, etc. The death rate in Croatia increases significantly. According to these statistics and knowledge, the major external factors, smoking / drinking, environmental pollution, late marriage / late childbearing, unhealthy sexual behavior, unhealthy dietary behavior, less physical excise, and workplace stress, etc., may have contributed to most cancer-induced deaths in Europe. http://www.iaees.org/publications/journals/np/articles/2018-3(1-2)/trend-of-cancer-induced-deaths-in-Europe.pdf malignant neoplasms death rates linear regression trend Europe