WenJun Zhang YanHong Qi School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China Sun Yat-sen University Library, Sun Yat-sen University, Guangzhou 510275, China Network Pharmacology ISSN 2415-1084 http://www.iaees.org/publications/journals/np/online-version.asp 2025 10 1-2 1 13 International Academy of Ecology and Environmental Sciences Hong Kong 2 January 2025 3 January 2025 1 June 2025 head tilt excise blood pressure hypertension cardiac rate rehabilitation cure In present study, the effect of head tilt excise for lowering blood pressure is experimented. The results show that there is a significant difference between systolic blood pressures before and during one-time excise, between diastolic blood pressures before and during one-time excise, and between cardiac rates before and during one-time excise. Systolic blood pressure and diastolic blood pressure will decline 7 mmHg and 3 mmHg during one-time head tilt excise. Cardiac rate will decline 2 beats/min during one-time head tilt excise. Systolic blood pressure benefits mostly from one-time head tilt excise, seconded by diastolic blood pressure, and cardiac rate benefits least from one-time head tilt excise. The effect of one-time head tilt excise for lowering systolic blood pressure and cardiac rate significantly increases with systolic blood pressure and cardiac rate respectively. There is a significant difference between systolic blood pressures before and after 15-min head tilt excise, and between diastolic blood pressures before and after 15-min head tilt excise. Systolic blood pressure and diastolic blood pressure will decline 8 mmHg and 5 mmHg respectively after 15-min head tilt excise. There is not significant difference between cardiac rates before and after 15-min head tilt excise. Systolic blood pressure benefits mostly from 15-min head tilt excise, seconded by diastolic blood pressure, and cardiac rate may not benefit from 15-min head tilt excise. The effect of 15-min head tilt excise for lowering systolic blood pressure, diastolic blood pressure and cardiac rate significantly increases with systolic blood pressure, diastolic blood pressure and cardiac rate respectively. The effect of 15-min head tilt excise in lowering diastolic blood pressure significantly increases with time (days). In average, diastolic blood pressure declines 6 mmHg after one month. The effect in systolic blood pressure slightly increases with time. However for cardiac rate, the effect is not significant. On the mechanism of head tilt excise in lowering blood pressure, we hold that tilting head back interferes with the transmission of nerve signals from the brain to the organs, weakens sympathetic nerve activity, stimulates vagus nerve activity, decreases the secretion of angiotensin and some other blood pressure related substances to blood vessels, and reduces cardiac rate. While the long-term exercise can cause the sympathetic nerve activity related to blood pressure to become permanently blunted and thus lead to permenent declining of blood pressure. Finally, we conclude that head tilt excise can be used as an effective treatment measure for instantly or permanently lowering blood pressure. http://www.iaees.org/publications/journals/np/articles/2025-10(1-2)/head-tilt-exercise-significantly-lowers-blood-pressure.pdf