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Selforganizology, 2020, 7(1-2): 1-7
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Article

A Matlab algorithm for detection of protein complexes from multiple heterogeneous networks

WenJun Zhang, ShangHong Xin
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; International Academy of Ecology and Environmental Sciences, Hong Kong

Received 12 October 2019;Accepted 18 December 2019;Published 1 June 2020
IAEES

Abstract
In present article, we presented the Matlab algorithm of Ou-Yang's model (Ou-Yang et al., 2017). It can be used to explore the shared clustering structure in PPI (protein-protein interaction) and DDI (domain-domain interaction) networks. A final matrix H can be achieved using the algorithm. Protein i belongs to complex k if Hik=1, otherwise Hik=0, i=1, 2, ..., N1; k=1, 2, ..., K, where N1 is the number of proteins in PPI network, and K is the number of complexes (clusters).

Keywords Matlab algorithm;Ou-Yang's model;protein-protein interactions;protein complexes;heterogeneous networks.



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