WenJun Zhang School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China Selforganizology ISSN 2410-0080 http://www.iaees.org/publications/journals/selforganizology/online-version.asp 2026 13 3-4 104 141 International Academy of Ecology and Environmental Sciences Hong Kong 12 August 2026 9 September 2026 1 December 2026 generative AI breakthrough innovation first principles counterfactual reasoning Bayesian inference causal inference human-AI hybrid intelligence computational creativity Generative artificial intelligence has achieved remarkable capabilities in content generation, code synthesis, and scientific assistance. Yet the question of whether such systems can produce breakthrough innovative thinking remains unresolved. This paper conducts a comprehensive literature review and critical analysis to address this question. This study operationalizes breakthrough innovative thinking as a five-dimensional construct comprising questioning default assumptions, redefining problems, cross-domain connection, systemic reconstruction, and rapid experimental validation. Drawing on references, this study systematically evaluates generative AI's performance across these dimensions. It is found that that generative AI excels as a statistical association engine, demonstrating strength in cross-domain connection and combinatorial generation, but exhibits significant limitations in problem redefinition, causal intervention, experimental validation, and social value commitment. This study diagnoses the fundamental deficiency not as statistical or Bayesian learning per se, but as a structural mismatch between predictive objectives and the requirements of breakthrough innovation. The study proposes the Three-Engine Four-Layer Coupling model, which posits that breakthrough innovation emerges from the coupled operation of a statistical generation engine, a counterfactual reconstruction engine, and an experimental validation engine, operating across statistical, counterfactual, causal-experimental, and social-value layers. I formalize this model and derive testable hypotheses. It is concluded that generative AI functions as a powerful probability amplifier for breakthrough innovation but cannot autonomously serve as a breakthrough agent. The future path lies in constructing human-AI-experiment-society coupled hybrid systems. http://www.iaees.org/publications/journals/selforganizology/articles/2026-13(3-4)/can-generative-AI-produce-breakthrough-innovative-thinking.pdf