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Network Biology, 2021, 11(4): 263-273
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Article

A statistical simulation method for causality inference of Boolean variables

WenJun Zhang
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

Received 6 August 2020;Accepted 28 September 2021;Published 1 December 2021
IAEES

Abstract
In present study, a statistical simulation method for causality inference of Boolean variables was proposed. First, I used statistical simulation to generate artificial data of two Boolean variables with known independent and dependent variables. A law was drawn from the simulation analysis of the artificial data. For a set of data of two Boolean variables, a randomization method was proposed and used to test the statistical significance of the Boolean correlation measure (point correlation, quartile correlation, or Jaccard correlation, etc.). The causality inference was then conducted to observed data based on the law. Finally, the statistical simulation was used to determine the statistic significance of the causality. Full Matlab codes were presented also.

Keywords causality inference;correlation;Boolean variables;randomization;statistical simulation;non-parametric statistics.

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