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Network Pharmacology, 2021, 6(1-2): 1-8
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Article

A discretized dynamic model to describe the development of insecticide resistance

WenJun Zhang1, GuangHua Liu2
1School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
2Guangdong AIB Polytech College, Guangzhou 510507, China

Received 27 July 2020;Accepted 18 August 2020;Published 1 June 2021
IAEES

Abstract
In this article, a discretized dynamic model was proposed to describe the development of insecticide resistance. Variables as dosage, timing and frequency of insecticide applications, mutation rate, insecticide-resistant individual's fitness, etc., were included in the model. The model was validated using sensitivity analysis. The model was finally used to evaluate the effect of mixed use of bioinsecticide and chemical insecticide to reduce insecticide resistance. The model can be used to predict the dynamic development of insecticide resistance and to evaluate the effect of various factors on insecticide resistance.

Keywords dynamic model;insecticide application;resistance development;insect's fitness;mutation rate.


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