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Network Pharmacology, 2025, 10(3-4): 14-65
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Article

A web-based data generator for Mendelian Randomization (MR) analysis

WenJun Zhang
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

Received 8 September 2025;Accepted 25 September 2025;Published online 1 October 2025;Published 1 December 2025
IAEES

Abstract
In present study, a data generator for Mendelian Randomization (MR) analysis was presented. It is a comprehensive web-based tool. The tool takes as input GWAS exposure and outcome data files, and outputs a JSON file for MR analysis. The SNPs correlation matrix is obtained from public databases or by AI (DeepSeek, Gemini, etc.) data construction or as the identity matrix. The tool supports both univariate and multivariate MR analyses. It provides an integrated workflow for processing genetic association data, automatic harmonization, correlation matrix generation, and MR input construction.

Keywords Mendelian Randomization (MR);data generator;web-based tool.


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